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ECHA Substances of Very High Concern
Substances restricted under REACH (Annex XVII)

1-methyl-2-pyrrolidone

CAS	872-50-4
EC	212-828-1

Entry number	71
Conditions	external link [echa.europa.eu]
History	R 2018/588 [eur-lex.europa.eu]
Q&As	entry 1603 [echa.europa.eu] entry 1828 [echa.europa.eu]
Remarks	Restriction guideline: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone). The document is published at https://echa.europa.eu/documents/10162/17233/entry_71_how_to_comply_en.pdf/c6e09198-c0b1-44e3-abae-6b3d0bc909a8 Explanatory note: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone), Explanatory Note on Biological Monitoring. The document is published at https://echa.europa.eu/documents/10162/17233/entry_71_exp_note_biomonitoring_en.pdf/25c684f2-243e-4321-e7c0-ba7074838ab6

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1-methyl-2-pyrrolidone
CAS: 872-50-4, EC: 212-828-1

Registry of CLH intentions until outcome
Deadline for commenting: 2013-10-11
Registry of restriction intentions
Restriction scope: Manufacturing, and all industrial and professional uses of the substance, where workers’ …
Registry of SVHC intentions until outcome
Scope: Toxic for reproduction (Article 57c)
Registered substances
Tonnage band: Intermediate use only
Registrants
Tonnage band: Intermediate use only
Registered substances
Tonnage band: ≥ 10000 to < 100000 tonnes
Registrants
Tonnage band: ≥ 10000 to < 100000 tonnes
Candidate List of SVHCs for Authorisation under the name 1-Methyl-2-pyrrolidone (NMP)
Scope: Toxic for reproduction (Article 57c)
Harmonised classification and labelling (CLP Annex VI) under the name N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone
Hazard Class and Category Codes: Repr. 1B: Reproductive toxicity; STOT SE 3: Specific target organ toxicity — single exposure; Skin Irrit. 2: Skin corrosion/irritation; Eye Irrit. 2: Serious eye damage/eye irritation

The following timeline shows when we detected changes of this regulatory record (the date might slightly differ from the date of the actual change). Additions between versions are hightlighted in green color, red color shows data removed between versions.

This version

July 13, 2022

Remarks: Restriction guideline: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone). The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_how_to_comply_en.pdf Explanatory note: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone), Explanatory Note on Biological Monitoring. The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_exp_note_biomonitoring_en.pdf → Restriction guideline: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone). The document is published at https://echa.europa.eu/documents/10162/17233/entry_71_how_to_comply_en.pdf/c6e09198-c0b1-44e3-abae-6b3d0bc909a8 Explanatory note: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone), Explanatory Note on Biological Monitoring. The document is published at https://echa.europa.eu/documents/10162/17233/entry_71_exp_note_biomonitoring_en.pdf/25c684f2-243e-4321-e7c0-ba7074838ab6

Previous version

June 4, 2021

Conditions: https://echa.europa.eu/documents/10162/e7598958-eae7-1661-0636-02778b427efc → https://echa.europa.eu/documents/10162/5161f2bf-503c-2107-ab54-c087017d11c9
Q&As / File Title: entry 1828
Q&As / Full Path: https://echa.europa.eu/support/qas-support/browse/-/qa/70Qx/view/ids/1828

Previous version #2

April 9, 2021

Name: 1-methyl-2-pyrrolidone;N-methyl-2-pyrrolidone → 1-methyl-2-pyrrolidone

Previous version #3

March 27, 2021

Name: 1-methyl-2-pyrrolidone → 1-methyl-2-pyrrolidone;N-methyl-2-pyrrolidone

Previous version #4

Aug. 20, 2019

Remarks: Restriction guideline: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone). The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_how_to_comply_en.pdf Explanatory note on biological monitoring: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone), Explanatory Note on Biological Monitoring. The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_exp_note_biomonitoring_en.pdf → Restriction guideline: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone). The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_how_to_comply_en.pdf Explanatory note: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone), Explanatory Note on Biological Monitoring. The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_exp_note_biomonitoring_en.pdf
Q&As / File Title: entry 1603
Q&As / Full Path: https://echa.europa.eu/support/qas-support/browse/-/qa/70Qx/view/ids/1603

Previous version #5

July 22, 2019

Remarks: Restriction guideline: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone). The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_how_to_comply_en.pdf Explanatory note on biological monitoring: How to comply with REACH Restriction 71, guideline for users of NMP (1-methyl-2-pyrrolidone), Explanatory Note on Biological Monitoring. The document is published at https://echa.europa.eu/documents/10162/13641/entry_71_exp_note_biomonitoring_en.pdf

Previous version #6

1-methyl-2-pyrrolidone

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